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The principal cytochrome P450 isoenzyme associated seems to be CYP2E1, with CYP1A2 and CYP3A4 as added pathways. Approximately 85% of the oral dose appears in the urine inside of 24 hrs of administration, most as being the glucuronide conjugate, with little quantities of other conjugates and unchanged drug [see OVERDOSAGE] for toxicity data.Infants